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Separation of atropisomers by chiral liquid chromatography and thermodynamic analysis of separation mechanism()
In the pharmaceutical industry, the analysis of atropisomers is of considerable interest from a scientific and regulatory perspective. The compound of interest contains two stereogenic axes due to the hindered rotation around the single bonds connecting the aryl groups, which results in four potenti...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Xi'an Jiaotong University
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790684/ https://www.ncbi.nlm.nih.gov/pubmed/29404032 http://dx.doi.org/10.1016/j.jpha.2017.03.003 |