Cargando…

A stability-indicating LC–MS/MS method for zidovudine: Identification, characterization and toxicity prediction of two major acid degradation products

Zidvovudine (AZT) is a nucleoside analogue reverse transcriptase inhibitor (NRTI), a class of anti-retroviral drug. A stability-indicating assay method for AZT was developed in line with ICH guideline. Successful separation of AZT and its degradation products was achieved by gradient elution mode on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Devrukhakar, Prashant S., Shiva Shankar, M., Shankar, G., Srinivas, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790685/ https://www.ncbi.nlm.nih.gov/pubmed/29404043 http://dx.doi.org/10.1016/j.jpha.2017.01.006

Ejemplares similares

LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
por: Rakibe, Uday, et al.
Publicado: (2018)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Characterization of the Oxidative Degradation Product of Darunavir by LC-MS/MS
por: Yamjala, Karthik, et al.
Publicado: (2015)

Selective separation, detection of zotepine and mass spectral characterization of degradants by LC–MS/MS/QTOF
por: Talluri, M.V.N. Kumar, et al.
Publicado: (2014)

Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS
por: Skibiński, Robert, et al.
Publicado: (2018)

Forced Degradation Behaviour of Fluphenazine Hydrochloride by LC and Characterization of its Oxidative Degradation Product by LC–MS/MS
por: Thummar, Kashyap N., et al.
Publicado: (2015)

Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF
por: CAN, Nafiz Öncü
Publicado: (2018)

Identification of Forced Degradation Products of Itopride by LC-PDA and LC-MS
por: Joshi, Payal, et al.
Publicado: (2011)

Identification and Characterization of Hydrolytic Degradation Products of Cefditoren Pivoxil using LC and LC-MS/TOF
por: Gawande, V. T., et al.
Publicado: (2015)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
por: Yao, Yu-Feng, et al.
Publicado: (2018)

Determination of Cefixime by a Validated Stability-Indicating HPLC Method and Identification of its Related Substances by LC-MS/MS Studies
por: Talebpour, Zahra, et al.
Publicado: (2013)

Establishment of inherent stability of pramipexole and development of validated stability indicating LC–UV and LC–MS method
por: Pawar, Shubhangi M., et al.
Publicado: (2013)

Metabolic Stability and Metabolite Characterization of Capilliposide B and Capilliposide C by LC–QTRAP–MS/MS
por: Cheng, Zhongzhe, et al.
Publicado: (2018)

Simultaneous determination of amlodipine, valsartan and hydrochlorothiazide by LC–ESI-MS/MS and its application to pharmacokinetics in rats
por: Gadepalli, Shankar Ganesh, et al.
Publicado: (2014)

LC-MS based stability-indicating method for studying the degradation of lonidamine under physical and chemical stress conditions
por: Rochani, Ankit Kanaiyalal, et al.
Publicado: (2020)

The LC-QTOF-MS/MS analysis of acid degradation products of Rifaximin, an antibiotic
por: Yaseen, Saima Baig, et al.
Publicado: (2022)

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS
por: Lam, Anh K., et al.
Publicado: (2022)

LC–UV and LC–MS evaluation of stress degradation behavior of desvenlafaxine
por: Pawar, Shubhangi M., et al.
Publicado: (2012)

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Determination of S-Adenosylmethionine and S-Adenosylhomocysteine by LC–MS/MS and evaluation of their stability in mice tissues
por: Krijt, Jakub, et al.
Publicado: (2009)

Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC–MS/MS
por: Shirangi, Mehrnoosh, et al.
Publicado: (2015)

Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2019)

Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats
por: Kim, Woojin, et al.
Publicado: (2023)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

LC-MS-based Metabolomics of Xenobiotic-induced Toxicities
por: Chen, Chi, et al.
Publicado: (2013)

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability
por: Kadi, Adnan A., et al.
Publicado: (2016)

Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS/MS Method
por: Yoo, In-Young, et al.
Publicado: (2018)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Stability Study and Handling Recommendations for Multiresidue Pesticide Mixes under Diverse Storage Conditions for LC–MS/MS and GC–MS/MS
por: Wiest, Landon A, et al.
Publicado: (2023)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Application of LC–MS/MS in the Mycotoxins Studies
por: Gámiz-Gracia, Laura, et al.
Publicado: (2020)

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics
por: Blaženović, Ivana, et al.
Publicado: (2018)

LC-MS/MS Method Development for the Discovery and Identification of Amphidinols Produced by Amphidinium
por: Wellkamp, Marvin, et al.
Publicado: (2020)

Modern Approaches in the Identification and Quantification of Immunogenic Peptides in Cereals by LC-MS/MS
por: Alves, Thais O., et al.
Publicado: (2019)

Proteome dataset of Hemileia vastatrix by LC–MS/MS label-free identification
por: Cury, Natália Faustino, et al.
Publicado: (2022)

LC-ESI-QTOF-MS/MS Characterization of Seaweed Phenolics and Their Antioxidant Potential
por: Zhong, Biming, et al.
Publicado: (2020)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
por: Zhang, Kai
Publicado: (2021)

LC-QTOF-MS Identification of Major Urinary Cyclopropylfentanyl Metabolites Using Synthesized Standards
por: Vikingsson, Svante, et al.
Publicado: (2019)

Identification of the major photodegradant in metronidazole by LC-PDA-MS and its reveal in compendial methods
por: Chen, Mei-Ling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_eu4g326cdd0eudanuqo2n7m581