Clinical Implications of Digenic Inheritance and Epistasis in Primary Immunodeficiency Disorders

The existence of epistasis in humans was first predicted by Bateson in 1909. Epistasis describes the non-linear, synergistic interaction of two or more genetic loci, which can substantially modify disease severity or result in entirely new phenotypes. The concept has remained controversial in human...

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Detalles Bibliográficos
Autores principales: Ameratunga, Rohan, Woon, See-Tarn, Bryant, Vanessa L., Steele, Richard, Slade, Charlotte, Leung, Euphemia Yee, Lehnert, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790765/
https://www.ncbi.nlm.nih.gov/pubmed/29434582
http://dx.doi.org/10.3389/fimmu.2017.01965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790765/
https://www.ncbi.nlm.nih.gov/pubmed/29434582
http://dx.doi.org/10.3389/fimmu.2017.01965

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