Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

BACKGROUND: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: d’Avila, Joana Costa, Siqueira, Luciana Domett, Mazeraud, Aurélien, Azevedo, Estefania Pereira, Foguel, Debora, Castro-Faria-Neto, Hugo Caire, Sharshar, Tarek, Chrétien, Fabrice, Bozza, Fernando Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791311/
https://www.ncbi.nlm.nih.gov/pubmed/29382344
http://dx.doi.org/10.1186/s12974-018-1059-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791311/
https://www.ncbi.nlm.nih.gov/pubmed/29382344
http://dx.doi.org/10.1186/s12974-018-1059-y

Ejemplares similares