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Never tear us a-PARP: Dealing with DNA lesions during mitosis
Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, sub...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791853/ https://www.ncbi.nlm.nih.gov/pubmed/29404385 http://dx.doi.org/10.1080/23723556.2017.1382670 |