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Never tear us a-PARP: Dealing with DNA lesions during mitosis

Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, sub...

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Detalles Bibliográficos
Autores principales:	Schoonen, Pepijn M., van Vugt, Marcel A.T.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Author's Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791853/ https://www.ncbi.nlm.nih.gov/pubmed/29404385 http://dx.doi.org/10.1080/23723556.2017.1382670

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