Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cell...

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Detalles Bibliográficos
Autores principales: Fujimaki, Kotaro, Yao, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791855/
https://www.ncbi.nlm.nih.gov/pubmed/29404395
http://dx.doi.org/10.1080/23723556.2017.1403531
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author Fujimaki, Kotaro
Yao, Guang
author_facet Fujimaki, Kotaro
Yao, Guang
author_sort Fujimaki, Kotaro
collection PubMed
description The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
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spelling pubmed-57918552018-12-18 Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy Fujimaki, Kotaro Yao, Guang Mol Cell Oncol Author's Views The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment. Taylor & Francis 2017-12-18 /pmc/articles/PMC5791855/ /pubmed/29404395 http://dx.doi.org/10.1080/23723556.2017.1403531 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Fujimaki, Kotaro
Yao, Guang
Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title_full Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title_fullStr Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title_full_unstemmed Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title_short Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
title_sort crack the state of silence: tune the depth of cellular quiescence for cancer therapy
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791855/
https://www.ncbi.nlm.nih.gov/pubmed/29404395
http://dx.doi.org/10.1080/23723556.2017.1403531
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