Cargando…
A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Targeting key regulators of the cancer stem cell phenotype to overcome their critical influence on tumor growth is a promising new strategy for cancer treatment. Here we present a modeling framework that operates at both the cellular and molecular levels, for investigating IL-6 mediated, cancer stem...
Autores principales: | Nazari, Fereshteh, Pearson, Alexander T., Nör, Jacques Eduardo, Jackson, Trachette L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792033/ https://www.ncbi.nlm.nih.gov/pubmed/29351275 http://dx.doi.org/10.1371/journal.pcbi.1005920 |
Ejemplares similares
-
A Mathematical Model of Cancer Stem Cell Driven Tumor Initiation: Implications of Niche Size and Loss of Homeostatic Regulatory Mechanisms
por: Gentry, Sara N., et al.
Publicado: (2013) -
A validated mathematical model of FGFR3-mediated tumor growth reveals pathways to harness the benefits of combination targeted therapy and immunotherapy in bladder cancer
por: Okuneye, Kamaldeen, et al.
Publicado: (2021) -
A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues
por: Bergman, Daniel, et al.
Publicado: (2022) -
Patient-derived xenograft (PDX) tumors increase growth rate with time
por: Pearson, Alexander T., et al.
Publicado: (2016) -
Sampling from single-cell observations to predict tumor cell growth in-vitro and in-vivo
por: Pearson, Alexander T., et al.
Publicado: (2017)