CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog

To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types. Most positive regulators identified in our screen...

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Detalles Bibliográficos
Autores principales: Pusapati, Ganesh V., Kong, Jennifer H., Patel, Bhaven B., Krishnan, Arunkumar, Sagner, Andreas, Kinnebrew, Maia, Briscoe, James, Aravind, L., Rohatgi, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792066/
https://www.ncbi.nlm.nih.gov/pubmed/29290584
http://dx.doi.org/10.1016/j.devcel.2017.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792066/
https://www.ncbi.nlm.nih.gov/pubmed/29290584
http://dx.doi.org/10.1016/j.devcel.2017.12.003

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