Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored red blood cell units is clinically relevant for transfused recipients...

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Detalles Bibliográficos
Autores principales: Nemkov, Travis, Sun, Kaiqi, Reisz, Julie A., Song, Anren, Yoshida, Tatsuro, Dunham, Andrew, Wither, Matthew J., Francis, Richard O., Roach, Robert C., Dzieciatkowska, Monika, Rogers, Stephen C., Doctor, Allan, Kriebardis, Anastasios, Antonelou, Marianna, Papassideri, Issidora, Young, Carolyn T., Thomas, Tiffany A., Hansen, Kirk C., Spitalnik, Steven L., Xia, Yang, Zimring, James C., Hod, Eldad A., D’Alessandro, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792281/
https://www.ncbi.nlm.nih.gov/pubmed/29079593
http://dx.doi.org/10.3324/haematol.2017.178608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792281/
https://www.ncbi.nlm.nih.gov/pubmed/29079593
http://dx.doi.org/10.3324/haematol.2017.178608

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