PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly

Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reco...

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Detalles Bibliográficos
Autores principales: Coleman, Jeff, Jouannot, Ouardane, Ramakrishnan, Sathish K., Zanetti, Maria N., Wang, Jing, Salpietro, Vincenzo, Houlden, Henry, Rothman, James E., Krishnakumar, Shyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792450/
https://www.ncbi.nlm.nih.gov/pubmed/29346777
http://dx.doi.org/10.1016/j.celrep.2017.12.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792450/
https://www.ncbi.nlm.nih.gov/pubmed/29346777
http://dx.doi.org/10.1016/j.celrep.2017.12.056

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