Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to selectively target HCC. Hepatic HK2 deletion inhibits tumor incidence in a mouse model of hepatocarcinogene...

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Detalles Bibliográficos
Autores principales: DeWaal, Dannielle, Nogueira, Veronique, Terry, Alexander R., Patra, Krushna C., Jeon, Sang-Min, Guzman, Grace, Au, Jennifer, Long, Christopher P., Antoniewicz, Maciek R., Hay, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792493/
https://www.ncbi.nlm.nih.gov/pubmed/29386513
http://dx.doi.org/10.1038/s41467-017-02733-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792493/
https://www.ncbi.nlm.nih.gov/pubmed/29386513
http://dx.doi.org/10.1038/s41467-017-02733-4

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