Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway

We aimed to elucidate the effects of iguratimod, a widely used anti-rheumatic drug with no severe side effects, on chronic experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Iguratimod was orally administered to mice immunised with myelin oligodendrocyte gly...

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Detalles Bibliográficos
Autores principales: Li, Guangrui, Yamasaki, Ryo, Fang, Mei, Masaki, Katsuhisa, Ochi, Hirofumi, Matsushita, Takuya, Kira, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792543/
https://www.ncbi.nlm.nih.gov/pubmed/29386552
http://dx.doi.org/10.1038/s41598-018-20390-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792543/
https://www.ncbi.nlm.nih.gov/pubmed/29386552
http://dx.doi.org/10.1038/s41598-018-20390-5

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