Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT(2B) receptor antagonists in vitro – a potential pathway affecting proliferation

Serotonin (5-hydroxytryptamine) has repeatedly been associated with the development of fibrotic disorders such as pulmonary fibrosis. By blocking the binding of 5-HT to 5-HT(2B) receptors with receptor antagonists, several pro-fibrotic mechanisms can be inhibited. Bleomycin-induced pulmonary fibrosi...

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Detalles Bibliográficos
Autores principales: Löfdahl, Anna, Rydell-Törmänen, Kristina, Larsson-Callerfelt, Anna-Karin, Wenglén, Christina, Westergren-Thorsson, Gunilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792547/
https://www.ncbi.nlm.nih.gov/pubmed/29386571
http://dx.doi.org/10.1038/s41598-018-20430-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792547/
https://www.ncbi.nlm.nih.gov/pubmed/29386571
http://dx.doi.org/10.1038/s41598-018-20430-0

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