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Pulmonary fibrosis in vivo displays increased p21 expression reduced by 5-HT(2B) receptor antagonists in vitro – a potential pathway affecting proliferation
Serotonin (5-hydroxytryptamine) has repeatedly been associated with the development of fibrotic disorders such as pulmonary fibrosis. By blocking the binding of 5-HT to 5-HT(2B) receptors with receptor antagonists, several pro-fibrotic mechanisms can be inhibited. Bleomycin-induced pulmonary fibrosi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792547/ https://www.ncbi.nlm.nih.gov/pubmed/29386571 http://dx.doi.org/10.1038/s41598-018-20430-0 |