Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation

F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (A...

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Detalles Bibliográficos
Autores principales: Ikenoue, Tsuneo, Terakado, Yumi, Zhu, Chi, Liu, Xun, Ohsugi, Tomoyuki, Matsubara, Daisuke, Fujii, Tomoki, Kakuta, Shigeru, Kubo, Sachiko, Shibata, Takuma, Yamaguchi, Kiyoshi, Iwakura, Yoichiro, Furukawa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792591/
https://www.ncbi.nlm.nih.gov/pubmed/29386660
http://dx.doi.org/10.1038/s41598-018-19769-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792591/
https://www.ncbi.nlm.nih.gov/pubmed/29386660
http://dx.doi.org/10.1038/s41598-018-19769-1

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