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Secretory factors from OP9 stromal cells delay differentiation and increase the expansion potential of adult erythroid cells in vitro

Development of in vitro culture systems for the generation of red blood cells is a goal of scientists globally with the aim of producing clinical grade products for transfusion. Although mature reticulocytes can be efficiently generated by such systems, the numbers produced fall short of that requir...

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Detalles Bibliográficos
Autores principales: Trakarnsanga, Kongtana, Wilson, Marieangela C., Heesom, Kate J., Andrienko, Tatyana N., Srisawat, Chatchawan, Frayne, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792592/
https://www.ncbi.nlm.nih.gov/pubmed/29386568
http://dx.doi.org/10.1038/s41598-018-20491-1