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The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix

Tarp (translocated actin recruiting phosphoprotein) is an effector protein common to all chlamydial species that functions to remodel the host-actin cytoskeleton during the initial stage of infection. In C. trachomatis, direct binding to actin monomers has been broadly mapped to a 100-residue region...

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Detalles Bibliográficos
Autores principales: Tolchard, James, Walpole, Samuel J., Miles, Andrew J., Maytum, Robin, Eaglen, Lawrence A., Hackstadt, Ted, Wallace, B. A., Blumenschein, Tharin M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792643/
https://www.ncbi.nlm.nih.gov/pubmed/29386631
http://dx.doi.org/10.1038/s41598-018-20290-8