Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes

[Image: see text] Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety of oligomeric and fibrillar...

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Detalles Bibliográficos
Autores principales: Chaibva, Maxmore, Gao, Xiang, Jain, Pranav, Campbell, Warren A., Frey, Shelli L., Legleiter, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793032/
https://www.ncbi.nlm.nih.gov/pubmed/29399649
http://dx.doi.org/10.1021/acsomega.7b01472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793032/
https://www.ncbi.nlm.nih.gov/pubmed/29399649
http://dx.doi.org/10.1021/acsomega.7b01472

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