Cargando…

Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes

[Image: see text] Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety of oligomeric and fibrillar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chaibva, Maxmore, Gao, Xiang, Jain, Pranav, Campbell, Warren A., Frey, Shelli L., Legleiter, Justin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793032/ https://www.ncbi.nlm.nih.gov/pubmed/29399649 http://dx.doi.org/10.1021/acsomega.7b01472

Ejemplares similares

Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation
por: Stonebraker, Alyssa R., et al.
Publicado: (2023)

Biophysical Insights into How Surfaces, Including Lipid Membranes, Modulate Protein Aggregation Related to Neurodegeneration
por: Burke, Kathleen A., et al.
Publicado: (2013)

Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers
por: Pifer, Phillip M., et al.
Publicado: (2011)

GM(1) Ganglioside Inhibits β‐Amyloid Oligomerization Induced by Sphingomyelin
por: Amaro, Mariana, et al.
Publicado: (2016)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin
por: Zheng, Kehong, et al.
Publicado: (2019)

Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
por: Sokoya, Tolulope, et al.
Publicado: (2022)

F-Actin Binding Regions on the Androgen Receptor and Huntingtin Increase Aggregation and Alter Aggregate Characteristics
por: Angeli, Suzanne, et al.
Publicado: (2010)

Polyglutamine disruption of the huntingtin exon1 N-terminus triggers a complex aggregation mechanism
por: Thakur, Ashwani K., et al.
Publicado: (2009)

Emphatic visualization of sphingomyelin-rich domains by inter-lipid FRET imaging using fluorescent sphingomyelins
por: Kinoshita, Masanao, et al.
Publicado: (2017)

TRiC’s tricks inhibit huntingtin aggregation
por: Shahmoradian, Sarah H, et al.
Publicado: (2013)

Detection of ubiquitinated huntingtin species in intracellular aggregates
por: Juenemann, Katrin, et al.
Publicado: (2015)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
por: He, Wen-Tian, et al.
Publicado: (2017)

Confirming a Drosophila Melanogaster Model of Huntingtin Aggregation
por: Biritwum, Akosua, et al.
Publicado: (2021)

Neuroprotective Effects of Calmodulin Peptide 76‐121aa: Disruption of Calmodulin Binding to Mutant Huntingtin
por: Dudek, Nichole L., et al.
Publicado: (2009)

ON THE COMPONENTS OF SPHINGOMYELIN
por: Levene, P. A.
Publicado: (1913)

The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation
por: Rudajev, Vladimir, et al.
Publicado: (2020)

Intermolecular interaction of phosphatidylinositol with the lipid raft molecules sphingomyelin and cholesterol
por: Kinoshita, Masanao, et al.
Publicado: (2008)

Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis
por: Segarra, Sergi, et al.
Publicado: (2023)

Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy
por: Zhu, Han, et al.
Publicado: (2023)

Long chain sphingomyelin depletes cholesterol from the cytoplasmic leaflet in asymmetric lipid membranes
por: Karlsen, Maria Lyngby, et al.
Publicado: (2021)

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation
por: Teuling, Eva, et al.
Publicado: (2011)

Tissue Transglutaminase Does Not Contribute to the Formation of Mutant Huntingtin Aggregates
por: Chun, Wanjoo, et al.
Publicado: (2001)

Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates
por: Mano, Tatsuo, et al.
Publicado: (2014)

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin
por: Tan, Z, et al.
Publicado: (2015)

Meso scale discovery-based assays for the detection of aggregated huntingtin
por: Reindl, Wolfgang, et al.
Publicado: (2019)

GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
por: Ahat, Erpan, et al.
Publicado: (2022)

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs
por: Kinoshita, Masanao, et al.
Publicado: (2017)

Identification of Binding Sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L
por: Sanders, Shaun S., et al.
Publicado: (2014)

Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining
por: Chapple, J. Paul, et al.
Publicado: (2008)

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
por: Yamamoto, Ai, et al.
Publicado: (2006)

Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1
por: Sahoo, Bankanidhi, et al.
Publicado: (2014)

Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast
por: Kantcheva, Ralitsa B., et al.
Publicado: (2014)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model
por: Carnemolla, Alisia, et al.
Publicado: (2017)

N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate
por: Gottlieb, Leah, et al.
Publicado: (2021)

Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models
por: Taniguchi, Makoto, et al.
Publicado: (2020)

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin
por: Enkavi, Giray, et al.
Publicado: (2017)

Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis
por: Goto, Asako, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ommh9714lj5geqinm84062pvtg