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Formation of 2-Imino Benzo[e]-1,3-oxazin-4-ones from Reactions of Salicylic Acids and Anilines with HATU: Mechanistic and Synthetic Studies

[Image: see text] We describe a new 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU)-mediated coupling reaction to produce 2-imino benzo[e]-1,3-oxazin-4-ones from salicylic acids and anilines. Mechanistic studies support a reaction pathway in whic...

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Detalles Bibliográficos
Autores principales: Leas, Derek A., Wu, Jianbo, Ezell, Edward L., Garrison, Jered C., Vennerstrom, Jonathan L., Dong, Yuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793036/
https://www.ncbi.nlm.nih.gov/pubmed/29399653
http://dx.doi.org/10.1021/acsomega.7b01824