The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels

The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, μ an...

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Detalles Bibliográficos
Autores principales: Freitas, Ana C. N., Peigneur, Steve, Macedo, Flávio H. P., Menezes-Filho, José E., Millns, Paul, Medeiros, Liciane F., Arruda, Maria A., Cruz, Jader, Holliday, Nicholas D., Tytgat, Jan, Hathway, Gareth, de Lima, Maria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793130/
https://www.ncbi.nlm.nih.gov/pubmed/29342943
http://dx.doi.org/10.3390/toxins10010043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793130/
https://www.ncbi.nlm.nih.gov/pubmed/29342943
http://dx.doi.org/10.3390/toxins10010043

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