Cargando…
The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels
The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, μ an...
Autores principales: | Freitas, Ana C. N., Peigneur, Steve, Macedo, Flávio H. P., Menezes-Filho, José E., Millns, Paul, Medeiros, Liciane F., Arruda, Maria A., Cruz, Jader, Holliday, Nicholas D., Tytgat, Jan, Hathway, Gareth, de Lima, Maria E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793130/ https://www.ncbi.nlm.nih.gov/pubmed/29342943 http://dx.doi.org/10.3390/toxins10010043 |
Ejemplares similares
-
A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems
por: da Fonseca Pacheco, Daniela, et al.
Publicado: (2016) -
From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma
por: da Silva, Carolina Nunes, et al.
Publicado: (2022) -
PnPP-19 Peptide as a Novel Drug Candidate for Topical Glaucoma Therapy Through Nitric Oxide Release
por: da Silva, Carolina Nunes, et al.
Publicado: (2020) -
PnPP-15, a Synthetic Peptide Derived from a Toxin from Phoneutria nigriventer Spider Venom, Alleviates Diabetic Neuropathic Pain and Acts Synergistically with Pregabalin in Mice
por: Mariano, Xavier Maia, et al.
Publicado: (2023) -
Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating
por: Peigneur, Steve, et al.
Publicado: (2018)