Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Here, we explore whether and how DNA damage repair might impact on these time-dependent changes, in particular in proliferative intestinal stem cells. We introduce a 3D multiscale computer model of intestinal crypts...

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Detalles Bibliográficos
Autores principales: Thalheim, Torsten, Herberg, Maria, Galle, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793170/
https://www.ncbi.nlm.nih.gov/pubmed/29303998
http://dx.doi.org/10.3390/genes9010017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793170/
https://www.ncbi.nlm.nih.gov/pubmed/29303998
http://dx.doi.org/10.3390/genes9010017

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