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Linking DNA Damage and Age-Related Promoter DNA Hyper-Methylation in the Intestine

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Here, we explore whether and how DNA damage repair might impact on these time-dependent changes, in particular in proliferative intestinal stem cells. We introduce a 3D multiscale computer model of intestinal crypts...

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Detalles Bibliográficos
Autores principales:	Thalheim, Torsten, Herberg, Maria, Galle, Joerg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793170/ https://www.ncbi.nlm.nih.gov/pubmed/29303998 http://dx.doi.org/10.3390/genes9010017

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