Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes

We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boun...

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Detalles Bibliográficos
Autores principales: Schorning, K, Dette, H, Kettelhake, K, Wong, W K, Bretz, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Miscellanea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793717/
https://www.ncbi.nlm.nih.gov/pubmed/29430043
http://dx.doi.org/10.1093/biomet/asx057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793717/
https://www.ncbi.nlm.nih.gov/pubmed/29430043
http://dx.doi.org/10.1093/biomet/asx057

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