Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes

We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boun...

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Detalles Bibliográficos
Autores principales: Schorning, K, Dette, H, Kettelhake, K, Wong, W K, Bretz, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Miscellanea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793717/
https://www.ncbi.nlm.nih.gov/pubmed/29430043
http://dx.doi.org/10.1093/biomet/asx057
Descripción
Sumario:We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boundary points of the design space are included in the optimal design. We provide an analytical description of minimally supported optimal designs and show that they do not depend on the correlation between the bivariate outcomes.

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