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Optimal designs for active controlled dose-finding trials with efficacy-toxicity outcomes
We derive optimal designs to estimate efficacy and toxicity in active controlled dose-finding trials when the bivariate continuous outcomes are described using nonlinear regression models. We determine upper bounds on the required number of different doses and provide conditions under which the boun...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793717/ https://www.ncbi.nlm.nih.gov/pubmed/29430043 http://dx.doi.org/10.1093/biomet/asx057 |