Cytosolic Proteostasis via Importing of Misfolded Proteins into Mitochondria

Loss of proteostasis underlies aging and neurodegeneration characterized by the accumulation of protein aggregates and mitochondrial dysfunction(1–5). Although many neurodegenerative-disease proteins can be found in mitochondria(4,6), it remains unclear how these disease manifestations may be relate...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruan, Linhao, Zhou, Chuankai, Jin, Erli, Kucharavy, Andrei, Zhang, Ying, Wen, Zhihui, Florens, Laurence, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793917/
https://www.ncbi.nlm.nih.gov/pubmed/28241148
http://dx.doi.org/10.1038/nature21695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793917/
https://www.ncbi.nlm.nih.gov/pubmed/28241148
http://dx.doi.org/10.1038/nature21695

Ejemplares similares