Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk

The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy th...

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Detalles Bibliográficos
Autores principales: Waller, Rosalie G., Darlington, Todd M., Wei, Xiaomu, Madsen, Michael J., Thomas, Alun, Curtin, Karen, Coon, Hilary, Rajamanickam, Venkatesh, Musinsky, Justin, Jayabalan, David, Atanackovic, Djordje, Rajkumar, S. Vincent, Kumar, Shaji, Slager, Susan, Middha, Mridu, Galia, Perrine, Demangel, Delphine, Salama, Mohamed, Joseph, Vijai, McKay, James, Offit, Kenneth, Klein, Robert J., Lipkin, Steven M., Dumontet, Charles, Vachon, Celine M., Camp, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794067/
https://www.ncbi.nlm.nih.gov/pubmed/29389935
http://dx.doi.org/10.1371/journal.pgen.1007111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794067/
https://www.ncbi.nlm.nih.gov/pubmed/29389935
http://dx.doi.org/10.1371/journal.pgen.1007111

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