RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition

The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR axis, although treatment resistance is a major problem. Here, we aimed to understand how RCC cells acquire resistance to PI3K-mTOR inhibition. We...

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Detalles Bibliográficos
Autores principales: Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L., Protheroe, Andrew S., Macaulay, Valentine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794101/
https://www.ncbi.nlm.nih.gov/pubmed/29389967
http://dx.doi.org/10.1371/journal.pone.0191890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794101/
https://www.ncbi.nlm.nih.gov/pubmed/29389967
http://dx.doi.org/10.1371/journal.pone.0191890

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