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Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide

Staphylococcus aureus requires branched-chain amino acids (BCAAs; isoleucine, leucine, valine) for protein synthesis, branched-chain fatty acid synthesis, and environmental adaptation by responding to their availability via the global transcriptional regulator CodY. The importance of BCAAs for S. au...

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Detalles Bibliográficos
Autores principales: Kaiser, Julienne C., King, Alyssa N., Grigg, Jason C., Sheldon, Jessica R., Edgell, David R., Murphy, Michael E. P., Brinsmade, Shaun R., Heinrichs, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794164/
https://www.ncbi.nlm.nih.gov/pubmed/29357354
http://dx.doi.org/10.1371/journal.pgen.1007159