Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila

Wolfram syndrome (WS), caused by loss-of-function mutations in the Wolfram syndrome 1 gene (WFS1), is characterized by juvenile-onset diabetes mellitus, bilateral optic atrophy, and a wide spectrum of neurological and psychiatric manifestations. WFS1 encodes an endoplasmic reticulum (ER)-resident tr...

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Detalles Bibliográficos
Autores principales: Sakakibara, Yasufumi, Sekiya, Michiko, Fujisaki, Naoki, Quan, Xiuming, Iijima, Koichi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794194/
https://www.ncbi.nlm.nih.gov/pubmed/29357349
http://dx.doi.org/10.1371/journal.pgen.1007196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794194/
https://www.ncbi.nlm.nih.gov/pubmed/29357349
http://dx.doi.org/10.1371/journal.pgen.1007196

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