PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction

Proprotein convertase subtilisin/kexin type 9 (PCSK9) interacts directly with cytoplasmic apoB and prevents its degradation via the autophagosome/lysosome pathway. This process affects VLDL and LDL production and influences atherogenesis. Here, we investigated the molecular machinery by which PCSK9...

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Detalles Bibliográficos
Autores principales: Sun, Hua, Krauss, Ronald M., Chang, Jeffrey T., Teng, Ba-Bie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794417/
https://www.ncbi.nlm.nih.gov/pubmed/29180444
http://dx.doi.org/10.1194/jlr.M078360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794417/
https://www.ncbi.nlm.nih.gov/pubmed/29180444
http://dx.doi.org/10.1194/jlr.M078360

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