Saline Accelerates Oxime Reaction with Aldehyde and Keto Substrates at Physiological pH

We have discovered a simple and versatile reaction condition for oxime mediated bioconjugation reaction that could be adapted for both aldehyde and keto substrates. We found that saline accelerated the oxime kinetics in a concentration-dependent manner under physiological conditions. The reaction me...

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Detalles Bibliográficos
Autores principales: Wang, Shujiang, Nawale, Ganesh N., Kadekar, Sandeep, Oommen, Oommen P., Jena, Naresh K., Chakraborty, Sudip, Hilborn, Jöns, Varghese, Oommen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794741/
https://www.ncbi.nlm.nih.gov/pubmed/29391582
http://dx.doi.org/10.1038/s41598-018-20735-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794741/
https://www.ncbi.nlm.nih.gov/pubmed/29391582
http://dx.doi.org/10.1038/s41598-018-20735-0

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