Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which are highly expressed on malignant cells but not on T cells. However, when T cells are engineered with CARs that recognize antigens expressed on...

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Detalles Bibliográficos
Autores principales: Han, Chungyong, Sim, Su-Jung, Kim, Seon-Hee, Singh, Rohit, Hwang, Sunhee, Kim, Yu I., Park, Sang H., Kim, Kwang H., Lee, Don G., Oh, Ho S., Lee, Sangeun, Kim, Young H., Choi, Beom K., Kwon, Byoung S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794762/
https://www.ncbi.nlm.nih.gov/pubmed/29391449
http://dx.doi.org/10.1038/s41467-018-02912-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794762/
https://www.ncbi.nlm.nih.gov/pubmed/29391449
http://dx.doi.org/10.1038/s41467-018-02912-x

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