β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation

β-Sitosterol (BS), a major bioactive constituent present in plants and vegetables has shown potent anticancer effect against many human cancer cells, but the underlying mechanism remain elusive on NSCLC cancers. We found that BS significantly inhibited the growth of A549 cells without harming normal...

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Detalles Bibliográficos
Autores principales: Rajavel, Tamilselvam, Packiyaraj, Pandian, Suryanarayanan, Venkatesan, Singh, Sanjeev Kumar, Ruckmani, Kandasamy, Pandima Devi, Kasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794769/
https://www.ncbi.nlm.nih.gov/pubmed/29391428
http://dx.doi.org/10.1038/s41598-018-20311-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794769/
https://www.ncbi.nlm.nih.gov/pubmed/29391428
http://dx.doi.org/10.1038/s41598-018-20311-6

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