A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses

The entorhinal cortex (EC) is one of the most vulnerable brain regions that is attacked during the early stage of Alzheimer’s disease (AD). Here, we report that the synaptic terminals of pyramidal neurons in the EC layer II (ECII(PN)) directly innervate CA1 parvalbumin (PV) neurons (CA1(PV)) and are...

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Detalles Bibliográficos
Autores principales: Yang, X, Yao, C, Tian, T, Li, X, Yan, H, Wu, J, Li, H, Pei, L, Liu, D, Tian, Q, Zhu, L-Q, Lu, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794875/
https://www.ncbi.nlm.nih.gov/pubmed/27671476
http://dx.doi.org/10.1038/mp.2016.151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794875/
https://www.ncbi.nlm.nih.gov/pubmed/27671476
http://dx.doi.org/10.1038/mp.2016.151

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