Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is anti-inflammatory by virtue of covalently attached phosphorylcholine. Previously we have reported that drug-like Small Molecule Analogues (SMAs) of its phosphorylcholine moiety can mimic ES-62 in protecting against di...

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Detalles Bibliográficos
Autores principales: Suckling, Colin J., Alam, Shahabuddin, Olson, Mark A., Saikh, Kamal U., Harnett, Margaret M., Harnett, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794923/
https://www.ncbi.nlm.nih.gov/pubmed/29391452
http://dx.doi.org/10.1038/s41598-018-20388-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794923/
https://www.ncbi.nlm.nih.gov/pubmed/29391452
http://dx.doi.org/10.1038/s41598-018-20388-z

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