Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy

A newly designed organoselenium compound, methyl substituted umbelliferone selenocyanate (MUS), was synthesized as a primary hit against the myelotoxic activity of carboplatin. MUS was administered at 6 mg/kg b.wt, p.o. in concomitant and pretreatment schedules with carboplatin (12 mg/kg b.wt, i.p....

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Detalles Bibliográficos
Autores principales: Patra, Arup Ranjan, Roy, Somnath Singha, Basu, Abhishek, Bhuniya, Avishek, Bhattacharjee, Arin, Hajra, Subhadip, Sk, Ugir Hossain, Baral, Rathindranath, Bhattacharya, Sudin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794964/
https://www.ncbi.nlm.nih.gov/pubmed/29391414
http://dx.doi.org/10.1038/s41598-018-19854-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794964/
https://www.ncbi.nlm.nih.gov/pubmed/29391414
http://dx.doi.org/10.1038/s41598-018-19854-5

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