Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties

Macular edema due to neovascular age-related macular degeneration, diabetes or retinal vein occlusion can cause central vision loss. Intravitreal treatment with antibody-based biopharmaceutical compounds designed to neutralize vascular endothelial growth factor (VEGF) has proven to be an efficient s...

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Detalles Bibliográficos
Autores principales: Sivertsen, Magne Sand, Jørstad, Øystein Kalsnes, Grevys, Algirdas, Foss, Stian, Moe, Morten Carstens, Andersen, Jan Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794981/
https://www.ncbi.nlm.nih.gov/pubmed/29391560
http://dx.doi.org/10.1038/s41598-018-20525-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794981/
https://www.ncbi.nlm.nih.gov/pubmed/29391560
http://dx.doi.org/10.1038/s41598-018-20525-8

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