Understanding non-linear effects from Hill-type dynamics with application to decoding of p53 signaling

Analytical equations are derived depicting four possible scenarios resulting from pulsed signaling of a system subject to Hill-type dynamics. Pulsed Hill-type dynamics involves the binding of multiple signal molecules to a receptor and occurs e.g., when transcription factor p53 orchestrates cancer p...

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Detalles Bibliográficos
Autores principales: Shi, Xiaomin, Reimers, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795017/
https://www.ncbi.nlm.nih.gov/pubmed/29391550
http://dx.doi.org/10.1038/s41598-018-20466-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795017/
https://www.ncbi.nlm.nih.gov/pubmed/29391550
http://dx.doi.org/10.1038/s41598-018-20466-2

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