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Understanding non-linear effects from Hill-type dynamics with application to decoding of p53 signaling
Analytical equations are derived depicting four possible scenarios resulting from pulsed signaling of a system subject to Hill-type dynamics. Pulsed Hill-type dynamics involves the binding of multiple signal molecules to a receptor and occurs e.g., when transcription factor p53 orchestrates cancer p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795017/ https://www.ncbi.nlm.nih.gov/pubmed/29391550 http://dx.doi.org/10.1038/s41598-018-20466-2 |