Cargando…

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

BACKGROUND: Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study. METHOD: One hundred fifty fresh tumours of breast cancer pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riaz, Syeda Kiran, Khan, Jahangir Sarwar, Shah, Syed Tahir Abbas, Wang, Fen, Ye, Lin, Jiang, Wen G., Malik, Muhammad Faraz Arshad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795292/ https://www.ncbi.nlm.nih.gov/pubmed/29329585 http://dx.doi.org/10.1186/s12964-017-0213-y

Ejemplares similares

Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells
por: Riaz, Syeda Kiran, et al.
Publicado: (2019)

Targeted Inhibition of Fibroblast Growth Factor Receptor 1-GLI Through AZD4547 and GANT61 Modulates Breast Cancer Progression
por: Riaz, Syeda Kiran, et al.
Publicado: (2021)

Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients
por: Ishfaq, Mehreen, et al.
Publicado: (2022)

Effect of MHC Linked 7-Gene Signature on Delayed Hepatocellular Carcinoma Recurrence
por: Tariq, Fomaz, et al.
Publicado: (2021)

Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer
por: Ullah, Farman, et al.
Publicado: (2015)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
por: Bell, Jonathan B., et al.
Publicado: (2018)

Metastatic Progression of an Aggressive Hepatoblastoma Involving the Left Atrium and Ventricle
por: Yılmaz, Emre, et al.
Publicado: (2023)

Risk factors for onset of delirium after neck of femur fracture surgery: a prospective observational study
por: Tahir, Muaaz, et al.
Publicado: (2018)

Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma
por: Jenkins, Noah C, et al.
Publicado: (2014)

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport
por: Bidet, Michel, et al.
Publicado: (2011)

PAM50 Intrinsic Subtype Profiles in Primary and Metastatic Breast Cancer Show a Significant Shift toward More Aggressive Subtypes with Prognostic Implications
por: Jørgensen, Charlotte Levin Tykjær, et al.
Publicado: (2021)

Aggressive Metastatic Chordoma in the Wrist
por: Abraham, Jasson, et al.
Publicado: (2014)

Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer
por: Sheng, Hui, et al.
Publicado: (2019)

Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
por: Heng, Benjamin, et al.
Publicado: (2020)

Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway
por: Wu, Xianqiu, et al.
Publicado: (2017)

P994: HEDGEHOG PATHWAY INVOLVEMENT IN MASTOCYTOSIS DEVELOPMENT
por: Polivka, L., et al.
Publicado: (2022)

Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
por: Kim, SungEun, et al.
Publicado: (2019)

Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma
por: Patra-Kneuer, Maria, et al.
Publicado: (2023)

Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy
por: Naqvi, Syed Hassan Abbas, et al.
Publicado: (2013)

MBRS-21. CLINICAL AGGRESSIVENESS OF TP53-WILD TYPE SONIC HEDGEHOG MEDULLOBLASTOMA WITH MYCN AMPLIFICATION
por: Mitani, Yuichi, et al.
Publicado: (2020)

Evaluation of multiple risk factors involved in the development of Diabetic Retinopathy
por: Anwar, Syeda Birjees, et al.
Publicado: (2019)

Phytochemical profiling and cytotoxic potential of Arnebia nobilis root extracts against hepatocellular carcinoma using in-vitro and in-silico approaches
por: Kiran, Asia, et al.
Publicado: (2023)

Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling
por: Zeng, Ling-Hui, et al.
Publicado: (2022)

Hedgehog Signaling: An Achilles’ Heel in Cancer
por: Niyaz, Madiha, et al.
Publicado: (2019)

Differential Involvement of Hedgehog Signaling in Butterfly Wing and Eyespot Development
por: Tong, Xiaoling, et al.
Publicado: (2012)

Aberrant Promoter Methylation at CpG Cytosines Induce the Upregulation of the E2F5 Gene in Breast Cancer
por: Ali, Arshad, et al.
Publicado: (2016)

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype
por: Biederstädt, Alexander, et al.
Publicado: (2020)

Aggressive B-cell lymphoma subtyping: a pathologists viewpoint
por: de Jong, Daphne
Publicado: (2019)

Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes
por: Camela, Elisa, et al.
Publicado: (2023)

Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness
por: Casas, Bárbara S., et al.
Publicado: (2017)

Trabecular Variant of Juvenile Aggressive Ossifying Fibroma
por: Rahman, Tabishur, et al.
Publicado: (2015)

Genetic Analysis of Hedgehog Signaling in Ventral Body Wall Development and the Onset of Omphalocele Formation
por: Matsumaru, Daisuke, et al.
Publicado: (2011)

Evaluating the effects of socioeconomic status on stroke and bleeding risk scores and clinical events in patients on oral anticoagulant for new onset atrial fibrillation
por: Ravvaz, Kourosh, et al.
Publicado: (2021)

Case report: Metastatic melanoma masquerading as apical hypertrophic cardiomyopathy
por: Ashraf, Muddasir, et al.
Publicado: (2022)

Young Onset Polyarticular Tophaceous Gout: Rare and Aggressive
por: Rana, Deepshikha, et al.
Publicado: (2021)

Psychopathology, trauma and delinquency: subtypes of aggression and their relevance for understanding young offenders
por: Steiner, Hans, et al.
Publicado: (2011)

Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer
por: Zhang, Sheng, et al.
Publicado: (2019)

UCA1 overexpression is associated with less aggressive subtypes of bladder cancer
por: Lebrun, Laetitia, et al.
Publicado: (2018)

APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers
por: Fennell, Lochlan J., et al.
Publicado: (2020)

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma
por: Razzaghi, Raud, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tk6812hnq7nh0uspfps1teup3h