Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine

BACKGROUND: (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine and subsequently to (2R,6R)-hydroxynorketamine in the liver. The metabolism of ketamine to hydroxynorketamine was recently demonstrated...

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Detalles Bibliográficos
Autores principales: Shirayama, Yukihiko, Hashimoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795355/
https://www.ncbi.nlm.nih.gov/pubmed/29155993
http://dx.doi.org/10.1093/ijnp/pyx108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795355/
https://www.ncbi.nlm.nih.gov/pubmed/29155993
http://dx.doi.org/10.1093/ijnp/pyx108

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