Cargando…
The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes
Mitochondria exert an immense amount of cytophysiological functions, but the structural basis of most of these processes is still poorly understood. Here we use cross-linking mass spectrometry to probe the organization of proteins in native mouse heart mitochondria. Our approach provides the largest...
Autores principales: | Liu, Fan, Lössl, Philip, Rabbitts, Beverley M., Balaban, Robert S., Heck, Albert J. R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Biochemistry and Molecular Biology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795388/ https://www.ncbi.nlm.nih.gov/pubmed/29222160 http://dx.doi.org/10.1074/mcp.RA117.000470 |
Ejemplares similares
-
Current Challenges in Elucidating Respiratory Supercomplexes in Mitochondria: Methodological Obstacles
por: Jang, Sehwan, et al.
Publicado: (2018) -
The diverse and expanding role of mass spectrometry in structural and molecular biology
por: Lössl, Philip, et al.
Publicado: (2016) -
Structure of intact human MCU supercomplex with the auxiliary MICU subunits
por: Zhuo, Wei, et al.
Publicado: (2020) -
Purification of Active Respiratory Supercomplex from Bovine Heart Mitochondria Enables Functional Studies
por: Shinzawa-Itoh, Kyoko, et al.
Publicado: (2016) -
Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes
por: Solsona-Vilarrasa, Estel, et al.
Publicado: (2019)