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High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release

Tetherin is an interferon-inducible antiviral protein that inhibits the release of a broad spectrum of enveloped viruses by retaining virions at the surface of infected cells. While the role of specific tetherin domains in antiviral activity is clearly established, the role of glycosylation in tethe...

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Detalles Bibliográficos
Autores principales: Waheed, Abdul A., Gitzen, Ariana, Swiderski, Maya, Freed, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795439/
https://www.ncbi.nlm.nih.gov/pubmed/29303997
http://dx.doi.org/10.3390/v10010026