Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

Both the MRTF–SRF and the YAP–TEAD transcriptional regulatory networks respond to extracellular signals and mechanical stimuli. We show that the MRTF–SRF pathway is activated in cancer-associated fibroblasts (CAFs). The MRTFs are required in addition to the YAP pathway for CAF contractile and proinv...

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Detalles Bibliográficos
Autores principales: Foster, Charles T., Gualdrini, Francesco, Treisman, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795783/
https://www.ncbi.nlm.nih.gov/pubmed/29317486
http://dx.doi.org/10.1101/gad.304501.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795783/
https://www.ncbi.nlm.nih.gov/pubmed/29317486
http://dx.doi.org/10.1101/gad.304501.117

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