Cargando…
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B(act) complex
The precise function of the trimeric retention and splicing (RES) complex in pre-mRNA splicing remains unclear. Here we dissected the role of RES during the assembly and activation of yeast spliceosomes. The efficiency of pre-mRNA splicing was significantly lower in the absence of the RES protein Sn...
Autores principales: | Bao, Penghui, Will, Cindy L., Urlaub, Henning, Boon, Kum-Loong, Lührmann, Reinhard |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795787/ https://www.ncbi.nlm.nih.gov/pubmed/29330354 http://dx.doi.org/10.1101/gad.308163.117 |
Ejemplares similares
-
Multiple RNA–RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome
por: Bao, Penghui, et al.
Publicado: (2018) -
Mass spectrometry–based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
por: Schmidt, Carla, et al.
Publicado: (2014) -
ATPγS stalls splicing after B complex formation but prior to spliceosome activation
por: Agafonov, Dmitry E., et al.
Publicado: (2016) -
Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns
por: Keiper, Sandra, et al.
Publicado: (2019) -
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
por: Pozzi, Berta, et al.
Publicado: (2017)