Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of α-Helical Membrane-Active Peptides

V13K, a 26-residue peptide, has been shown to have strong antimicrobial activity, negligible hemolytic activity, and significant anticancer activity. In the present work, V13K was used as the framework to investigate the influence of helicity, as influenced by d-amino acid substitutions in the cente...

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Detalles Bibliográficos
Autores principales: Sun, Shiyu, Zhao, Guangxu, Huang, Yibing, Cai, Mingjun, Yan, Qiuyan, Wang, Hongda, Chen, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796017/
https://www.ncbi.nlm.nih.gov/pubmed/29280948
http://dx.doi.org/10.3390/ijms19010067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796017/
https://www.ncbi.nlm.nih.gov/pubmed/29280948
http://dx.doi.org/10.3390/ijms19010067

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